Biological descriptionPotent competitive NMDA antagonist. Centrally active following systemic administration.
Also available in simple stock solutions (ab146715) - add 1 ml of water to get an exact, ready-to-use concentration.
Chemical name(R)-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid
Storage instructionsStore at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for (R)-CPPene (SDZ EAA 494) (ab120232)
This product has been referenced in:
Park CK et al. Efficacy of D-CPPene, a competitive N-methyl-D-aspartate antagonist in focal cerebral ischemia in the rat. Neurosci Lett147:41-4 (1992).
Read more (PubMed: 1480321) »
Lowe DA et al. D-CPP-ene (SDZ EAA 494), a potent and competitive N-methyl-D-aspartate (NMDA) antagonist: effect on spontaneous activity and NMDA-induced depolarizations in the rat neocortical slice preparation, compared with other CPP derivatives and MK-801. Neurosci Lett113:315-21 (1990).
Read more (PubMed: 2166255) »
Patel S et al. Anticonvulsant activity of the NMDA antagonists, D(-)4-(3-phosphonopropyl) piperazine-2-carboxylic acid (D-CPP) and D(-)(E)-4-(3-phosphonoprop-2-enyl) piperazine-2-carboxylic acid (D-CPPene) in a rodent and a primate model of reflex epilepsy. Epilepsy Res7:3-10 (0).
Read more (PubMed: 2292244) »