Biological descriptionPotent and selective norepinephrine reuptake inhibitor. Ki values are 5, 77 and 1451 nM for inhibitors NET, DAT and SERT, respectively. Increases extraneuronal norepinephrine and dopamine levels within brain regions associated with Attention Deficit Hyperactivity Disorder.
Chemical name(R)-N-Methyl-γ-(2-methylphenoxy)benzenepropanamine hydrochloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for (R)-Tomoxetine hydrochloride (ab120758)
This product has been referenced in:
Swanson CJ et al. Effect of the attention deficit/hyperactivity disorder drug atomoxetine on extracellular concentrations of norepinephrine and dopamine in several brain regions of the rat. Neuropharmacology50:755-60 (2006).
Read more (PubMed: 16427661) »
Bymaster FP et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology27:699-711 (2002).
Read more (PubMed: 12431845) »