Anti-RAB11B antibody [KT80] (ab95375)
Key features and details
- Rat monoclonal [KT80] to RAB11B
- Suitable for: ICC/IF, WB
- Reacts with: Mouse
- Isotype: IgG2a
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-RAB11B antibody [KT80]
See all RAB11B primary antibodies -
Description
Rat monoclonal [KT80] to RAB11B -
Host species
Rat -
Tested applications
Suitable for: ICC/IF, WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Fusion protein corresponding to Mouse Rab11.
Database link: P46638 -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
ab95375 is purified from culture supernatants using a Protein G column. -
Clonality
Monoclonal -
Clone number
KT80 -
Isotype
IgG2a -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab95375 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ICC/IF |
1/100.
|
|
WB | (2) |
1/500 - 1/10000. Predicted molecular weight: 24 kDa.
|
Notes |
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ICC/IF
1/100. |
WB
1/500 - 1/10000. Predicted molecular weight: 24 kDa. |
Target
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Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. -
Sequence similarities
Belongs to the small GTPase superfamily. Rab family. -
Post-translational
modificationsCitrullinated by PADI4. -
Cellular localization
Recycling endosome membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasmic vesicle, phagosome membrane. Recruited to phagosomes containing S.aureus. - Information by UniProt
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Database links
- Entrez Gene: 19326 Mouse
- SwissProt: P46638 Mouse
- Unigene: 387587 Mouse
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Alternative names
- GTP-binding protein ypt3 antibody
- H YPT3 antibody
- RAB11B antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (9)
ab95375 has been referenced in 9 publications.
- Tan X et al. A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma. J Clin Invest 131:N/A (2021). PubMed: 32931483
- Sharoar MG et al. Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains. Mol Neurodegener 16:45 (2021). PubMed: 34215298
- Kadgien CA et al. Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition. Mol Brain 14:143 (2021). PubMed: 34530877
- Sun J et al. PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. Sci Rep 10:9824 (2020). PubMed: 32555345
- Che Y et al. KRAS regulation by small non-coding RNAs and SNARE proteins. Nat Commun 10:5118 (2019). PubMed: 31712554
- Scavuzzo MA et al. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA. Cell Rep 25:3811-3827.e7 (2018). PubMed: 30590051
- Del Cid-Pellitero E et al. Homeostatic Changes in GABA and Glutamate Receptors on Excitatory Cortical Neurons during Sleep Deprivation and Recovery. Front Syst Neurosci 11:17 (2017). PubMed: 28408870
- Tjondrokoesoemo A et al. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Hum Mol Genet 25:1192-202 (2016). PubMed: 26744329
- Vanhoutte D et al. Thrombospondin expression in myofibers stabilizes muscle membranes. Elife 5:N/A (2016). WB ; Mouse . PubMed: 27669143