Overview

  • Product nameAnti-RAB7B antibody
    See all RAB7B primary antibodies
  • Description
    Mouse monoclonal to RAB7B
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: DIWRGDVLAK IVPMEQSYPM VLLGNKIDLA DRKVPQEVAQ GWCREKDIPY FEVSAKNDIN VVQAFEMLAS RALSRYQSIL ENHLTESIKL SPDQSRSRCC , corresponding to amino acids 100-200 of Human RAB7B.

  • Positive control
    • A431, HL60 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab58029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionControls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
    • Tissue specificityExpressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
    • Sequence similaritiesBelongs to the small GTPase superfamily. Rab family.
    • Cellular localizationLate endosome. Lysosome. Golgi apparatus > trans-Golgi network. Golgi apparatus.
    • Information by UniProt
    • Database links
    • Alternative names
      • MGC16212 antibody
      • MGC9726 antibody
      • RAB7 antibody
      • rab7B antibody
      • RAB7B, member RAS oncogene family antibody
      • RAB7B_HUMAN antibody
      • Ras related protein Rab 7b antibody
      • Ras-related protein Rab-7B antibody
      see all

    Anti-RAB7B antibody images

    • RAB7 antibody (ab58029) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human small Intestine.


    • Predicted band size : 23 kDa

    References for Anti-RAB7B antibody (ab58029)

    ab58029 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab58029.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"