Overview

  • Product nameAnti-RAB7B antibody
    See all RAB7B primary antibodies
  • Description
    Mouse polyclonal to RAB7B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length human RAB7B (aa 1-199; AAH17092.1).

  • Positive control
    • RAB7B transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab77064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).

Target

  • FunctionControls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
  • Tissue specificityExpressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte.
  • Sequence similaritiesBelongs to the small GTPase superfamily. Rab family.
  • Cellular localizationLate endosome. Lysosome. Golgi apparatus > trans-Golgi network. Golgi apparatus.
  • Information by UniProt
  • Database links
  • Alternative names
    • MGC16212 antibody
    • MGC9726 antibody
    • RAB7 antibody
    • rab7B antibody
    • RAB7B, member RAS oncogene family antibody
    • RAB7B_HUMAN antibody
    • Ras related protein Rab 7b antibody
    • Ras-related protein Rab-7B antibody
    see all

Anti-RAB7B antibody images

  • All lanes : Anti-RAB7B antibody (ab77064) at 5 µg/ml

    Lane 1 : RAB7B transfected 293T cell lysate
    Lane 2 : Non-transfected transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 22 kDa
    Observed band size : 22 kDa

References for Anti-RAB7B antibody (ab77064)

ab77064 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"