Overview

  • Product name
  • Description
    Rabbit polyclonal to Rabex5
  • Specificity
    At least four isoforms of Rabex5 are known to exist; ab113480 will recognize all four. ab113480 is predicted to not cross-react with other LRRFIP family members.
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide containing a 19 residue sequence from the central region of Human Rabex5 (GenBank accession no. NP_055319).

  • Positive control
    • Rat brain tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab113480 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 79 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • Function
    Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
  • Sequence similarities
    Contains 1 A20-type zinc finger.
    Contains 1 VPS9 domain.
  • Post-translational
    modifications
    Monoubiquitinated.
  • Cellular localization
    Cytoplasm. Early endosome. Recycling endosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • RAB guanine nucleotide exchange factor (GEF) 1 antibody
    • Rab5 GDP/GTP exchange factor antibody
    • Rab5ef antibody
    • Rabaptin 5 associated exchange factor for Rab5 antibody
    • Rabaptin-5-associated exchange factor for Rab5 antibody
    • Rabex 5 antibody
    • Rabex-5 antibody
    • RABGEF 1 antibody
    • Rabgef1 antibody
    • RABX 5 antibody
    • RABX5 antibody
    • RABX5_HUMAN antibody
    • RAP1 antibody
    • Rin 2 antibody
    • Rin2 antibody
    see all

Images

  • Lane 1 : Anti-Rabex5 antibody (ab113480) at 1 µg/ml
    Lane 2 : Anti-Rabex5 antibody (ab113480) at 2 µg/ml

    Lane 1 : Human liver tissue lysate
    Lane 2 : Human liver tissue lysate


    Predicted band size : 79 kDa
  • Immunohistochemical staining of Rabex5 in mouse brain tissue with ab113480 at 20 ug/mL.

  • Anti-Rabex5 antibody (ab113480) at 1 µg/ml + Rat brain tissue lysate at 15 µg

    Predicted band size : 79 kDa
  • Immunohistochemical analysis of mouse brain tissue, staining Rabex5 with ab113480 at 5 µg/ml.

References

This product has been referenced in:
  • Kang L  et al. RABEX-5 overexpression in gastric cancer is correlated with elevated MMP-9 level. Am J Transl Res 8:2365-74 (2016). Read more (PubMed: 27347344) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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