Overview

  • Product name
    rac BHFF
  • Description
    Potent, selective GABAB positive allosteric modulator
  • Biological description
    Potent, selective GABAB positive allosteric modulator. Enhances GABAB agonist-stimulated responses in the FLIPR assay and [35S]GTPγS binding. Enhances inhibitory effect of baclofen on population spike (PS) in hippocampal slices. Orally active in vivo, displaying anxiolytic-like properties.
  • Purity
    > 95%

Properties

References

This product has been referenced in:
  • Maccioni P  et al. The positive allosteric modulator of the GABA(B) receptor, rac-BHFF, suppresses alcohol self-administration. Drug Alcohol Depend 109:96-103 (2010). Read more (PubMed: 20089372) »
  • Malherbe P  et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br J Pharmacol 154:797-811 (2008). Read more (PubMed: 18536733) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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