The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 21 kDa.
FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Tissue specificityHematopoietic specific.
Involvement in diseaseDefects in RAC2 are the cause of neutrophil immunodeficiency syndrome (NEUID) [MIM:608203].
Sequence similaritiesBelongs to the small GTPase superfamily. Rho family.
Cellular localizationCytoplasm. Membrane-associated when activated.