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ab992 has been referenced in 80 publications.

  • Quigley IK & Kintner C Rfx2 Stabilizes Foxj1 Binding at Chromatin Loops to Enable Multiciliated Cell Gene Expression. PLoS Genet 13:e1006538 (2017). ChIP ; Xenopus laevis . PubMed: 28103240
  • Jerkovic I  et al. Genome-Wide Binding of Posterior HOXA/D Transcription Factors Reveals Subgrouping and Association with CTCF. PLoS Genet 13:e1006567 (2017). PubMed: 28103242
  • Herdman C  et al. A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription. PLoS Genet 13:e1006899 (2017). PubMed: 28715449
  • Stelloh C  et al. The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing. Epigenetics Chromatin 9:14 (2016). PubMed: 27087855
  • Yun J  et al. Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability. Nucleic Acids Res 44:558-72 (2016). PubMed: 26420833
  • Leonetti MD  et al. A scalable strategy for high-throughput GFP tagging of endogenous human proteins. Proc Natl Acad Sci U S A 113:E3501-8 (2016). PubMed: 27274053
  • Wiechens N  et al. The Chromatin Remodelling Enzymes SNF2H and SNF2L Position Nucleosomes adjacent to CTCF and Other Transcription Factors. PLoS Genet 12:e1005940 (2016). PubMed: 27019336
  • Uusküla-Reimand L  et al. Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders. Genome Biol 17:182 (2016). WB, ChIP . PubMed: 27582050
  • Rahman S  et al. Cohesin recruits the Esco1 acetyltransferase genome wide to repress transcription and promote cohesion in somatic cells. Proc Natl Acad Sci U S A 112:11270-5 (2015). PubMed: 26305936
  • Majumder K  et al. Domain-Specific and Stage-Intrinsic Changes in Tcrb Conformation during Thymocyte Development. J Immunol 195:1262-72 (2015). ChIP ; Mouse . PubMed: 26101321
  • Qiu Z  et al. Functional interactions between NURF and Ctcf regulate gene expression. Mol Cell Biol 35:224-37 (2015). PubMed: 25348714
  • Savic D  et al. CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins. Genome Res 25:1581-9 (2015). PubMed: 26355004
  • de Wit E  et al. CTCF Binding Polarity Determines Chromatin Looping. Mol Cell 60:676-84 (2015). PubMed: 26527277
  • Guo Y  et al. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell 162:900-10 (2015). PubMed: 26276636
  • Laitem C  et al. CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription. Transcription 6:79-90 (2015). WB . PubMed: 26399478
  • Lavagnolli T  et al. Initiation and maintenance of pluripotency gene expression in the absence of cohesin. Genes Dev 29:23-38 (2015). WB, ChIP . PubMed: 25561493
  • Balog J  et al. Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4. Epigenetics 10:1133-42 (2015). ChIP . PubMed: 26575099
  • Kim LK  et al. Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells. Mol Cell 54:56-66 (2014). PubMed: 24613343
  • Rousseau M  et al. Classifying leukemia types with chromatin conformation data. Genome Biol 15:R60 (2014). ChIP . PubMed: 24995990
  • Gosalia N  et al. Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus. Nucleic Acids Res 42:9612-22 (2014). ChIP ; Human . PubMed: 25081205
  • Court F  et al. The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus. Epigenetics Chromatin 7:5 (2014). ChIP . PubMed: 24667089
  • Xu H  et al. Cohesin Rad21 mediates loss of heterozygosity and is upregulated via Wnt promoting transcriptional dysregulation in gastrointestinal tumors. Cell Rep 9:1781-97 (2014). PubMed: 25464844
  • Günal-Sadik G  et al. Stage-specific binding profiles of cohesin in resting and activated B lymphocytes suggest a role for cohesin in immunoglobulin class switching and maturation. PLoS One 9:e111748 (2014). ChIP ; Mouse . PubMed: 25375358
  • Yun WJ  et al. The hematopoietic regulator TAL1 is required for chromatin looping between the ß-globin LCR and human ?-globin genes to activate transcription. Nucleic Acids Res 42:4283-93 (2014). WB ; Human . PubMed: 24470145
  • Dluhosova M  et al. Epigenetic control of SPI1 gene by CTCF and ISWI ATPase SMARCA5. PLoS One 9:e87448 (2014). ChIP ; Human . PubMed: 24498324
  • Chen HS  et al. Epigenetic deregulation of the LMP1/LMP2 locus of Epstein-Barr virus by mutation of a single CTCF-cohesin binding site. J Virol 88:1703-13 (2014). PubMed: 24257606
  • Winters T  et al. Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion. EMBO J 33:1256-70 (2014). PubMed: 24797474
  • Matsumoto K  et al. Construction of mate pair full-length cDNAs libraries and characterization of transcriptional start sites and termination sites. Nucleic Acids Res N/A:N/A (2014). ChIP ; Human . PubMed: 25034687
  • Quintin J  et al. Dynamic estrogen receptor interactomes control estrogen-responsive trefoil Factor (TFF) locus cell-specific activities. Mol Cell Biol 34:2418-36 (2014). PubMed: 24752895
  • Makhlouf M  et al. A prominent and conserved role for YY1 in Xist transcriptional activation. Nat Commun 5:4878 (2014). PubMed: 25209548
  • Xu M  et al. CTCF controls HOXA cluster silencing and mediates PRC2-repressive higher-order chromatin structure in NT2/D1 cells. Mol Cell Biol 34:3867-79 (2014). PubMed: 25135475
  • Stong N  et al. Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline. Genome Res 24:1039-50 (2014). ChIP ; Human . PubMed: 24676094
  • Tark-Dame M  et al. Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction: insight into chromatin folding by polymer modelling. PLoS Comput Biol 10:e1003877 (2014). PubMed: 25299688
  • Heidari N  et al. Genome-wide map of regulatory interactions in the human genome. Genome Res 24:1905-17 (2014). Human . PubMed: 25228660
  • Iglesias-Platas I  et al. Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop. Nucleic Acids Res 41:2171-9 (2013). ChIP ; Human . PubMed: 23295672
  • Li W  et al. Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation. Nature 498:516-20 (2013). PubMed: 23728302
  • Choi NM  et al. Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom v gene rearrangement frequencies. J Immunol 191:2393-402 (2013). PubMed: 23898036
  • Seitan VC  et al. Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome Res 23:2066-77 (2013). ChIP ; Human . PubMed: 24002784
  • Aldridge S  et al. AHT-ChIP-seq: a completely automated robotic protocol for high-throughput chromatin immunoprecipitation. Genome Biol 14:R124 (2013). ChIP . PubMed: 24200198
  • Hahn M  et al. Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin. Genes Dev 27:859-72 (2013). ChIP . PubMed: 23599346
  • Mousavi K  et al. eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci. Mol Cell 51:606-17 (2013). PubMed: 23993744
  • Jeyasekharan AD  et al. A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Nat Struct Mol Biol 20:1191-8 (2013). PubMed: 24013206
  • Monahan K  et al. Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of protocadherin-a gene expression. Proc Natl Acad Sci U S A 109:9125-30 (2012). PubMed: 22550178
  • Faure AJ  et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res 22:2163-75 (2012). PubMed: 22780989
  • McEwan MV  et al. Cohesin is required for activation of MYC by estradiol. PLoS One 7:e49160 (2012). WB . PubMed: 23145106
  • Watanabe T  et al. Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells. Mol Cell Biol 32:1529-41 (2012). ChIP . PubMed: 22354988
  • Ren L  et al. CTCF mediates the cell-type specific spatial organization of the Kcnq5 locus and the local gene regulation. PLoS One 7:e31416 (2012). ChIP ; Human . PubMed: 22347474
  • Smits BM  et al. An insulator loop resides between the synthetically interacting elements of the human/rat conserved breast cancer susceptibility locus MCS5A/Mcs5a. Nucleic Acids Res 40:132-47 (2012). ChIP . PubMed: 21914726
  • Brown AC  et al. Epigenetic regulation of the latency-associated region of Marek's disease virus in tumor-derived T-cell lines and primary lymphoma. J Virol 86:1683-95 (2012). ChIP . PubMed: 22090140
  • Lin YC  et al. Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol 13:1196-204 (2012). ChIP ; Mouse . PubMed: 23064439
  • Guo C  et al. Two forms of loops generate the chromatin conformation of the immunoglobulin heavy-chain gene locus. Cell 147:332-43 (2011). ChIP . PubMed: 21982154
  • Nativio R  et al. Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome. Hum Mol Genet 20:1363-74 (2011). ChIP . PubMed: 21282187
  • Taberlay PC  et al. Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell 147:1283-94 (2011). ChIP ; Human . PubMed: 22153073
  • Ebert A  et al. The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells. Immunity 34:175-87 (2011). PubMed: 21349430
  • Tang M  et al. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A 108:15231-6 (2011). PubMed: 21896759
  • Xiao T  et al. Specific Sites in the C Terminus of CTCF Interact with the SA2 Subunit of the Cohesin Complex and Are Required for Cohesin-Dependent Insulation Activity. Mol Cell Biol 31:2174-83 (2011). WB ; Human . PubMed: 21444719
  • Chatterjee S  et al. Dynamic changes in binding of immunoglobulin heavy chain 3' regulatory region to protein factors during class switching. J Biol Chem 286:29303-12 (2011). ChIP ; Mouse . PubMed: 21685395
  • Kahyo T  et al. A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion. Oncogene 30:4453-63 (2011). PubMed: 21532624
  • Paakinaho V  et al. Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions. Mol Endocrinol 24:511-25 (2010). PubMed: 20093418
  • Ramachandrareddy H  et al. BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells. Proc Natl Acad Sci U S A : (2010). ChIP ; Human . PubMed: 20547840
  • Manning AL  et al. Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev 24:1364-76 (2010). WB, ICC/IF ; Human . PubMed: 20551165
  • Schmidt D  et al. A CTCF-independent role for cohesin in tissue-specific transcription. Genome Res 20:578-88 (2010). ChIP ; Human . PubMed: 20219941
  • Chang J  et al. Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus. Proc Natl Acad Sci U S A 107:21836-41 (2010). ChIP . PubMed: 21106760
  • Liu J  et al. Transcriptional dysregulation in NIPBL and cohesin mutant human cells. PLoS Biol 7:e1000119 (2009). ChIP . PubMed: 19468298
  • Sekimata M  et al. CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity 31:551-64 (2009). PubMed: 19818655
  • Lee JH  et al. Chromatin analysis of occluded genes. Hum Mol Genet 18:2567-74 (2009). ChIP . PubMed: 19380460
  • Degner SC  et al. Cutting edge: developmental stage-specific recruitment of cohesin to CTCF sites throughout immunoglobulin loci during B lymphocyte development. J Immunol 182:44-8 (2009). ChIP ; Mouse . PubMed: 19109133
  • Hadjur S  et al. Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature 460:410-3 (2009). ChIP ; Mouse . PubMed: 19458616
  • Bowers SR  et al. A conserved insulator that recruits CTCF and cohesin exists between the closely related but divergently regulated interleukin-3 and granulocyte-macrophage colony-stimulating factor genes. Mol Cell Biol 29:1682-93 (2009). ChIP ; Human . PubMed: 19158269
  • Røe OD  et al. Genome-wide profile of pleural mesothelioma versus parietal and visceral pleura: the emerging gene portrait of the mesothelioma phenotype. PLoS One 4:e6554 (2009). IHC-P ; Human . PubMed: 19662092
  • Liu J  et al. SMC1A expression and mechanism of pathogenicity in probands with X-Linked Cornelia de Lange syndrome. Hum Mutat 30:1535-42 (2009). WB ; Human . PubMed: 19701948
  • Li Z  et al. Characterization of viral and human RNAs smaller than canonical MicroRNAs. J Virol 83:12751-8 (2009). WB ; Human . PubMed: 19812168
  • Wendt KS  et al. Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature : (2008). ChIP ; Human . PubMed: 18235444
  • Hou C  et al. CTCF-dependent enhancer-blocking by alternative chromatin loop formation. Proc Natl Acad Sci U S A 105:20398-403 (2008). ChIP ; Mouse . PubMed: 19074263
  • Lefevre P  et al. The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription. Mol Cell 32:129-39 (2008). ChIP . PubMed: 18851839
  • Inoue A  et al. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Cell Cycle 6:1646-54 (2007). PubMed: 17611414
  • Díaz-Martínez LA  et al. Regulation of centromeric cohesion by sororin independently of the APC/C. Cell Cycle 6:714-24 (2007). PubMed: 17361102
  • Díaz-Martínez LA  et al. Cohesin is dispensable for centromere cohesion in human cells. PLoS ONE 2:e318 (2007). WB ; Human . PubMed: 17389909
  • Seitan VC  et al. Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. PLoS Biol 4:e242 (2006). PubMed: 16802858
  • Giménez-Abián JF  et al. Regulated separation of sister centromeres depends on the spindle assembly checkpoint but not on the Anaphase Promoting Complex/Cyclosome. Cell Cycle 4:1561-75 (2005). PubMed: 16205119

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