Overview

  • Product nameAnti-Radixin antibody
    See all Radixin primary antibodies
  • Description
    Goat polyclonal to Radixin
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Dog
  • Immunogen

    Synthetic peptide (

    C-QARDETKKTQND

    ) from an internal region of Human Radixin.

  • Positive control
    • WB: Human tonsil, lymph node and spleen lysates IHC-P: Human kidney and placenta tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab111064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 69 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionProbably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
  • Involvement in diseaseDefects in RDX are the cause of deafness autosomal recessive type 24 (DFNB24) [MIM:611022]. DFNB24 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • Sequence similaritiesContains 1 FERM domain.
  • DomainThe N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ablilty to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN.
  • Post-translational
    modifications
    Phosphorylated by tyrosine-protein kinases.
  • Cellular localizationCell membrane. Cytoplasm > cytoskeleton. Cleavage furrow. Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
  • Information by UniProt
  • Database links
  • Alternative names
    • CB567 antibody
    • CG12537 antibody
    • DFNB24 antibody
    • ESP10 antibody
    • Hh-induced MATH and BTB domain-containing protein antibody
    • HIB antibody
    • Moesin-B antibody
    • Protein roadkill antibody
    • RADI_HUMAN antibody
    • Radixin antibody
    • RDX antibody
    see all

Anti-Radixin antibody images

  • ab111064, at 2.5 µg/ml, staining Radixin in formalin-fixed, paraffin-embedded Human kidney tissue.
  • ab111064, at 2.5 µg/ml, staining Radixin in formalin-fixed, paraffin-embedded Human placenta tissue.
  • Anti-Radixin antibody (ab111064) at 0.03 µg/ml + Human Tonsil lysate (in RIPA buffer) at 35 µg/ml

    Predicted band size : 69 kDa

References for Anti-Radixin antibody (ab111064)

ab111064 has not yet been referenced specifically in any publications.

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