Overview

  • Product nameAnti-RAGEF2 antibody
    See all RAGEF2 primary antibodies
  • Description
    Mouse monoclonal to RAGEF2
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: LFPVVKKDMT FLHEGNDSKV DGLVNFEKLR MISKEIRQVV RMTSANMDPA MMFRQRSLSQ GSTNSNMLDV QGGAHKKRAR RSSLLNAKKL YEDAQMARK, corresponding to amino acids 1012-1111 of Human RAGEF2

Properties

Applications

Our Abpromise guarantee covers the use of ab57221 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionGuanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
    • Tissue specificityIsoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.
    • Sequence similaritiesContains 1 cyclic nucleotide-binding domain.
      Contains 1 N-terminal Ras-GEF domain.
      Contains 1 PDZ (DHR) domain.
      Contains 1 Ras-associating domain.
      Contains 1 Ras-GEF domain.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm. Cell membrane. Upon binding to M-Ras, it translocates to the plasma membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp667N084 antibody
      • DKFZp686I15116 antibody
      • KIA001LB antibody
      • PDZ domain containing guanine nucleotide exchange factor (GEF) 2 antibody
      • PDZ domain containing guanine nucleotide exchange factor 2 antibody
      • PDZ domain containing guanine nucleotide exchange factor I antibody
      • PDZ domain-containing guanine nucleotide exchange factor 2 antibody
      • PDZ GEF 2 antibody
      • PDZ GEF2 antibody
      • PDZ-GEF2 antibody
      • PDZGEF 2 antibody
      • PDZGEF2 antibody
      • RA GEF 2 antibody
      • RA GEF2 antibody
      • RA-GEF-2 antibody
      • RAGEF 2 antibody
      • Rap guanine nucleotide exchange factor (GEF) 6 antibody
      • Rap guanine nucleotide exchange factor 2 antibody
      • Rap guanine nucleotide exchange factor 6 antibody
      • RAPGEF6 antibody
      • RPGF6_HUMAN antibody
      see all

    Anti-RAGEF2 antibody images

    • RAGEF2 antibody (ab57221) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human pancreas.


    • Predicted band size : 179 kDa
      RAGEF2 antibody (ab57221) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-RAGEF2 antibody (ab57221)

    ab57221 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57221.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"