Overview

  • Product name
  • Description
    Rabbit polyclonal to RALB
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Zebrafish
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-182 of Human RALB (NP_002872).

  • Positive control
    • HepG2 whole cell lysate; 293T, A431, H1299, HeLa S3, Molt-4 and Raji cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab96456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 23 kDa.

Target

  • Function
    Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.
  • Sequence similarities
    Belongs to the small GTPase superfamily. Ras family.
  • Post-translational
    modifications
    Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
  • Cellular localization
    Cell membrane. During late cytokinesis localizes at the midbody.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5730472O18Rik antibody
    • dRalb antibody
    • GTP binding protein antibody
    • Ralb antibody
    • RALB_HUMAN antibody
    • RAS like protein B antibody
    • RAS like proto oncogene B antibody
    • Ras related GTP binding protein B antibody
    • Ras-related protein Ral-B antibody
    • v ral simian leukemia viral oncogene homolog B (ras related GTP binding protein) antibody
    • v ral simian leukemia viral oncogene homolog B (ras related) antibody
    • V ral simian leukemia viral oncogene homolog B antibody
    see all

Images

  • Anti-RALB antibody (ab96456) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 23 kDa

References

ab96456 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab96456.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up