Overview

  • Product nameAnti-Ran antibody
    See all Ran primary antibodies
  • Description
    Goat polyclonal to Ran
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Dog, Xenopus laevis
  • Immunogen

    Synthetic peptide: AAQGEPQVQFKLV, corresponding to amino acids 2-14 of Human Ran.

  • Positive control
    • A431 and Jurkat whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab17033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 26 kDa).Can be blocked with Human Ran peptide (ab23304).

Target

  • FunctionGTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
    Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
  • Tissue specificityExpressed in a variety of tissues.
  • Sequence similaritiesBelongs to the small GTPase superfamily. Ran family.
  • Post-translational
    modifications
    The N-terminus is blocked.
  • Cellular localizationNucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • Androgen receptor associated protein 24 antibody
    • Androgen receptor-associated protein 24 antibody
    • ARA 24 antibody
    • ARA24 antibody
    • Gsp1 antibody
    • GTP binding nuclear protein RAN antibody
    • GTP-binding nuclear protein Ran antibody
    • GTPase Ran antibody
    • Guanosine triphosphatase Ran antibody
    • LPS antibody
    • OK/SW-cl.81 antibody
    • ran antibody
    • RAN member RAS oncogene family antibody
    • RAN_HUMAN antibody
    • RanGTPase antibody
    • Ras like protein TC4 antibody
    • Ras related nuclear protein antibody
    • Ras-like protein TC4 antibody
    • Ras-related nuclear protein antibody
    • RASL2 8 antibody
    • TC 4 antibody
    • TC4 antibody
    see all

Anti-Ran antibody images

  • Anti-Ran antibody (ab17033) at 1 µg/ml + Cell lysates prepared from human A431 cells at 35 µg

    Predicted band size : 26 kDa

References for Anti-Ran antibody (ab17033)

ab17033 has not yet been referenced specifically in any publications.

Product Wall



I am sorry to confirm this antibody has not been tested for which form of RAN it can detect. I can only confirm that the immunogen as provided on the datasheet:

Synthetic peptide: AAQGEPQVQFKLV, corresponding to amino acids 2-14 of...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"