Anti-Ran antibody [ARAN1] (ab13049)

Overview

  • Product nameAnti-Ran antibody [ARAN1]
    See all Ran primary antibodies
  • Description
    Mouse monoclonal [ARAN1] to Ran
  • Tested applicationsSuitable for: WB, IP, ELISA, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Hamster, Cow, Human, Xenopus laevis
  • Immunogen

    Denatured recombinant protein (Human).

  • EpitopeThe antibody epitope is located at the C-terminus (amino acids 207-216), which is highly negatively charged.
  • Positive control
    • Jurkat cells extract.
  • General notesStorage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab13049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 25 kDa.
IP Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.

Target

  • FunctionGTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
    Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
  • Tissue specificityExpressed in a variety of tissues.
  • Sequence similaritiesBelongs to the small GTPase superfamily. Ran family.
  • Post-translational
    modifications
    The N-terminus is blocked.
  • Cellular localizationNucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • Database links
  • Alternative names
    • Androgen receptor associated protein 24 antibody
    • Androgen receptor-associated protein 24 antibody
    • ARA 24 antibody
    • ARA24 antibody
    • Gsp1 antibody
    • GTP binding nuclear protein RAN antibody
    • GTP-binding nuclear protein Ran antibody
    • GTPase Ran antibody
    • Guanosine triphosphatase Ran antibody
    • LPS antibody
    • OK/SW-cl.81 antibody
    • ran antibody
    • RAN member RAS oncogene family antibody
    • RAN_HUMAN antibody
    • RanGTPase antibody
    • Ras like protein TC4 antibody
    • Ras related nuclear protein antibody
    • Ras-like protein TC4 antibody
    • Ras-related nuclear protein antibody
    • RASL2 8 antibody
    • TC 4 antibody
    • TC4 antibody
    see all

References for Anti-Ran antibody [ARAN1] (ab13049)

ab13049 has not yet been referenced specifically in any publications.

Product Wall

Hello!

The information from the laboratory is as follows:

We would expect this antibody to recognise human, bovine, mouse, hamster, Xenopus lawvis Ran, which is approximately 25kDa.

Unfortunately we do not have information on...

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Thank you for your call yesterday and for your patience while I have been in touch with the lab regarding your enquiry.

Unfortunately we don't have any IF images available that were generated in-house, however I have found an article that con...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"