GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
Expressed in a variety of tissues.
Belongs to the small GTPase superfamily. Ran family.
The N-terminus is blocked.
Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Wang F et al. Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-ß2 and Ran GTPase in human glioblastoma cells. Oncotarget6:21468-78 (2015).
Read more (PubMed: 26056081) »