Overview

  • Product nameAnti-RanBP3 antibody
    See all RanBP3 primary antibodies
  • Description
    Mouse monoclonal to RanBP3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: KESLAESAAA YTKATARKCL LEKVEVITGE EAESNVLQMQ CKLFVFDKTS QSWLLRHPHP SHPAVGPCLC GEQPALCPCP GLPNYRPGTP AQLGGLLVRV , corresponding to amino acids 298-397 of Human RanBP3

Properties

Applications

Our Abpromise guarantee covers the use of ab56341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActs as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
    • Tissue specificityWidely expressed with high levels in testis and heart.
    • Sequence similaritiesContains 1 RanBD1 domain.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • DKFZp586I1520 antibody
      • Ran binding protein 3 antibody
      • Ran-binding protein 3 antibody
      • RANB3_HUMAN antibody
      • RanBP3 antibody
      see all

    Anti-RanBP3 antibody images

    • Western blot against tagged recombinant protein immunogen using ab56341 RanBP3 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-RanBP3 antibody (ab56341)

    ab56341 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"