Overview

  • Product nameAnti-RanBP3 antibody
    See all RanBP3 primary antibodies
  • Description
    Rabbit polyclonal to RanBP3
  • Tested applicationsSuitable for: ICC/IF, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Xenopus laevis, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Xenopus tropicalis , Platypus (Ornithorhynchus anatinus)
  • Immunogen

    Synthetic peptide corresponding to a region between residue 150 and 200 of Human RanBP3 (NP_015561.1)

  • Positive control
    • Human Controls: Anaplastic Thyroid Carcinoma, Breast Carcinoma, Colon Carcinoma, Linitis Plastica Stomach Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma, Stomach Adenocarcinoma, Testicular Seminoma
      Mouse Controls: Teratoma

Properties

Applications

Our Abpromise guarantee covers the use of ab84672 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/100.
IHC-P 1/100 - 1/500. Antigen retrieval is not essential but may optimise staining. The use of citrate buffer will enhance staining. Likely to work in frozen sections.

Target

  • FunctionActs as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
  • Tissue specificityWidely expressed with high levels in testis and heart.
  • Sequence similaritiesContains 1 RanBD1 domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DKFZp586I1520 antibody
    • Ran binding protein 3 antibody
    • Ran-binding protein 3 antibody
    • RANB3_HUMAN antibody
    • RanBP3 antibody
    see all

Anti-RanBP3 antibody images

  • ab84672 at 1/100 dilution staining RanBP3 in Human colon carcinoma by Immunofluorescence Formalin-fixed, Paraffin-embedded tissue. Detection: Red-fluorescent goat antirabbit IgG highly cross-adsorbed Antibody Hilyte PlusTM 555 at a dilution of 1/100.
  • ab84672 at 1/250 dilution staining RanBP3 in Human prostate carcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining
  • ab84672 at 1/250 dilution staining RanBP3 in Mouse teratoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

References for Anti-RanBP3 antibody (ab84672)

ab84672 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"