Recombinant
RabMAb

Anti-RANTES antibody [EPR1359] (ab108933)

Overview

  • Product name
    Anti-RANTES antibody [EPR1359]
    See all RANTES primary antibodies
  • Description
    Rabbit monoclonal [EPR1359] to RANTES
  • Tested applications
    Suitable for: WB, ICCmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within Human RANTES.

  • Positive control
    • RANTES recombinant protein
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab108933 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50000. Predicted molecular weight: 10 kDa.
ICC 1/100 - 1/250.
  • Application notes
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • Function
      Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils.
    • Tissue specificity
      T-cell and macrophage specific.
    • Sequence similarities
      Belongs to the intercrine beta (chemokine CC) family.
    • Post-translational
      modifications
      N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
      The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
    • Cellular localization
      Secreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Beta chemokine RANTES antibody
      • Beta chemokine RANTES precursor antibody
      • C C motif chemokine 5 antibody
      • CCL 5 antibody
      • CCL5 antibody
      • CCL5_HUMAN antibody
      • Chemokine (C C motif) ligand 5 antibody
      • Chemokine CC Motif Ligand 5 antibody
      • D17S136E antibody
      • EoCP antibody
      • Eosinophil chemotactic cytokine antibody
      • MGC17164 antibody
      • RANTES(4-68) antibody
      • Regulated upon activation normally T expressed and presumably secreted antibody
      • SCYA 5 antibody
      • SCYA5 antibody
      • SIS delta antibody
      • SIS-delta antibody
      • SISd antibody
      • Small inducible cytokine A5 (RANTES) antibody
      • Small inducible cytokine A5 antibody
      • Small inducible cytokine subfamily A (Cys Cys) member 5 antibody
      • Small-inducible cytokine A5 antibody
      • T cell specific protein p288 antibody
      • T cell specific RANTES protein antibody
      • T cell-specific protein P228 antibody
      • T-cell-specific protein RANTES antibody
      • TCP 228 antibody
      • TCP228 antibody
      see all

    Images

    • Anti-RANTES antibody [EPR1359] (ab108933) at 1/50000 dilution + RANTES recombinant protein at 0.01 µg

      Predicted band size : 10 kDa

    References

    ab108933 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Thank you for contacting us.

    The protein sequence compatibility between human and mouse with bovine is about 80% which is very close for antibody cross reactivity. We unfortunately haven't tested any of the antibody with bovine CCL5 so I am so...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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