FunctionSmall GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
Tissue specificityExpressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.
Sequence similaritiesBelongs to the small GTPase superfamily. Ras family.
Post-translational modificationsPalmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.