Anti-RARS2 antibody - C-terminal (ab175978)

Overview

  • Product name
    Anti-RARS2 antibody - C-terminal
  • Description
    Rabbit polyclonal to RARS2 - C-terminal
  • Tested applications
    Suitable for: Flow Cyt, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide within Human RARS2 aa 377-406 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q5T160

  • Positive control
    • HepG2 cell lysate, Human lung carcinoma tissue, NCI-H292 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab175978 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/10 - 1/50. ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/1000. Predicted molecular weight: 66 kDa.

Target

  • Involvement in disease
    Defects in RARS2 are the cause of pontocerebellar hypoplasia type 6 (PCH6) [MIM:611523]; also known as fatal infantile encephalopathy with mitochondrial respiratory chain defects. Pontocerebellar hypoplasia (PCH) is a heterogeneous group of disorders characterized by an abnormally small cerebellum and brainstem.
  • Sequence similarities
    Belongs to the class-I aminoacyl-tRNA synthetase family.
  • Cellular localization
    Mitochondrion matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • arginine tRNA ligase antibody
    • arginyl tRNA synthetase 2 mitochondrial antibody
    • Arginyl tRNA synthetase antibody
    • Arginyl-tRNA synthetase antibody
    • ArgRS antibody
    • DALRD2 antibody
    • mitochondrial antibody
    • PCH6 antibody
    • Probable arginine tRNA ligase antibody
    • probable arginine tRNA ligase mitochondrial antibody
    • Probable arginine--tRNA ligase antibody
    • probable arginyl tRNA synthetase mitochondrial antibody
    • RARS2 antibody
    • RARSL antibody
    • SYRM_HUMAN antibody
    see all

Images

  • Anti-RARS2 antibody - C-terminal (ab175978) at 1/1000 dilution + HepG2 cell lysate at 35 µg

    Predicted band size : 66 kDa
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung carcinoma tissue, labeling RARS2 with ab175978 at 1/10 dilution. ab175978 was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

  • Flow cytometric analysis of NCI-H292 cells, labeling RARS2 with 175978 at 1/10 dilution (bottom histogram; green), compared with a negative control cell (top histogram; blue).

References

ab175978 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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