Overview

  • Product nameAnti-RASA1 antibody
    See all RASA1 primary antibodies
  • Description
    Rabbit polyclonal to RASA1
  • Tested applicationsSuitable for: WB, IP, IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab18841 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 4 µg/ml. Detects a band of approximately 120 kDa.
IP Use a concentration of 20 µg/ml.
IHC-Fr Use a concentration of 20 µg/ml.

Target

  • FunctionInhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.
  • Tissue specificityIn placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
  • Involvement in diseaseNote=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas.
    Defects in RASA1 are the cause of capillary malformation-arteriovenous malformation (CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.
    Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
  • Sequence similaritiesContains 1 C2 domain.
    Contains 1 PH domain.
    Contains 1 Ras-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • Post-translational
    modifications
    The N-terminus is blocked.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • CM AVM antibody
    • CMAVM antibody
    • DKFZp434N071 antibody
    • GAP antibody
    • GTPase activating protein antibody
    • GTPase-activating protein antibody
    • OTTHUMP00000222390 antibody
    • OTTHUMP00000222391 antibody
    • OTTHUMP00000222392 antibody
    • OTTHUMP00000222393 antibody
    • p120GAP antibody
    • p120RASGAP antibody
    • PKWS antibody
    • Ras GTPase-activating protein 1 antibody
    • RAS p21 protein activator (GTPase activating protein) 1 antibody
    • Ras p21 protein activator antibody
    • RASA antibody
    • RASA1 antibody
    • RASA1_HUMAN antibody
    • RasGAP antibody
    • Triphosphatase activating protein antibody
    see all

References for Anti-RASA1 antibody (ab18841)

ab18841 has not yet been referenced specifically in any publications.

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