Overview

  • Product name
    Rasagiline mesylate
  • Description
    MAO-B inhibitor
  • Alternative names
    • Azilect
  • Biological description
    Selective, irreversible monoamine oxidase B (MAO-B) inhibitor, with anti-Parkinson activity. In cell culture (PC-12 and neuroblastoma SH-SY5Y cells) it exhibits neuroprotective and anti-apoptotic activity against several neurotoxins.
  • Purity
    > 99%

Properties

  • Chemical name
    (1R)-2,3-Dihydro-N-2-propyn-1-yl-1H-Inden-1-amine methanesulfonate
  • Molecular weight
    267.34
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C12H13N.CH3SO3H
  • CAS Number
    161735-79-1
  • PubChem identifier
    3052775
  • Storage instructions
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CS(=O)(=O)O.C#CCN[C@@H]2CCc1ccccc12
  • Source

    Synthetic

  • Research areas

    Rasagiline mesylate images

    • ab131457 staining Bcl2 in SK-N-SH cells treated with rasagiline mesylate (ab120236), by ICC/IF. Increase in Bcl2 expression correlates with increased concentration of rasagiline mesylate, as described in literature.
      The cells were incubated at 37°C for 24h in media containing different concentrations of ab120236 (rasagiline mesylate) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab131457 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    References for Rasagiline mesylate (ab120236)

    This product has been referenced in:
    • Weinreb O  et al. Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain. J Neural Transm 116:1457-72 (2009). Read more (PubMed: 19396396) »
    • Mandel S  et al. Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives. Brain Res Brain Res Rev 48:379-87 (2005). Read more (PubMed: 15850677) »
    • Youdim MB & Weinstock M Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell Mol Neurobiol 21:555-73 (2001). Read more (PubMed: 12043833) »

    See 0 Publications for this product

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    We have Rasagiline mesylate (http://www.abcam.com/Rasagiline-mesylate-ab120236.html) available as 10 mg or 50 mg portions. These are not provided in a pill form.

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