The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 20 µg/ml.
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 30 kDa).
Use at an assay dependent concentration.
FunctionGTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.
Tissue specificityPancreatic endocrine cells (islets of Langerhans).
Sequence similaritiesBelongs to the small GTPase superfamily. RasD family.
Post-translational modificationsFarnesylated. Farnesylation is required for membrane targeting.