Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab32171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • 5 Hydroxytryptamine 2C receptor
    • 5-HT-1C
    • 5-ht-1c receptor
    • 5-HT-2C
    • 5-HT1C
    • 5-HT2C
    • 5-HTR2C
    • 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
    • 5-hydroxytryptamine receptor 1C
    • 5-hydroxytryptamine receptor 2C
    • 5HT1C
    • 5HT2C
    • 5HT2C_HUMAN
    • 5HTR2C
    • 5Hydroxytryptamine 2C receptor
    • Htr1c
    • HTR2C
    • serotonin 1c receptor
    • serotonin 2c receptor
    • Serotonin 5-HT-2C receptor
    • Serotonin receptor 2C
    see all
  • Function
    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Domain
    The PDZ domain-binding motif is involved in the interaction with MPDZ.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

This product has been referenced in:
  • Yu HJ & Yamaguchi A Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis. J Neurophysiol 103:648-58 (2010). Blocking . Read more (PubMed: 19955293) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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