Rat Calcium Sensing Receptor peptide (ab41761)

Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Rat
    • Sequence
      ALAWHSSAYGPDQRAQ
    • Amino acids
      12 to 27

Specifications

Our Abpromise guarantee covers the use of ab41761 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Neutralising

    Blocking

  • Purity
    > 95 % SDS-PAGE.
    >95% pure.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Ca sensing receptor
    • Ca2+ sensing receptor
    • Ca2+ sensing receptor 1
    • Calcium sensing receptor
    • CAR
    • CaSR
    • CASR_HUMAN
    • EIG8
    • Extracellular calcium sensing receptor
    • Extracellular calcium sensing receptor [Precursor]
    • Extracellular calcium-sensing receptor
    • FHH
    • FIH
    • GPRC2A
    • HHC
    • HHC1
    • Hypocalciuric hypercalcemia 1
    • Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism
    • MGC138441
    • NSHPT
    • Parathyroid Ca(2+) sensing receptor 1
    • Parathyroid Cell calcium sensing receptor
    • Parathyroid Cell calcium-sensing receptor
    • PCAR 1
    • PCaR1
    see all
  • Function
    Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
  • Tissue specificity
    Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.
  • Involvement in disease
    Defects in CASR are the cause of familial hypocalciuric hypercalcemia type 1 (FHH) [MIM:145980]. FHH is characterized by altered calcium homeostasis. Affected individuals exhibit mild or modest hypercalcemia, relative hypocalciuria, and inappropriately normal PTH levels.
    Defects in CASR are the cause of neonatal severe primary hyperparathyroidism (NSHPT) [MIM:239200]. NSHPT is a rare autosomal recessive life-threatening disorder characterized by very high serum calcium concentrations, skeletal demineralization, and parathyroid hyperplasia. In some instances NSHPT has been demonstrated to be the homozygous form of FHH.
    Defects in CASR are a cause of familial isolated hypoparathyroidism (FIH) [MIM:146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. An autosomal recessive form of FIH also exists.
    Defects in CASR are the cause of idiopathic generalized epilepsy type 8 (IGE8) [MIM:612899]; also known as EIG8. A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Seizure types are variable, but include myoclonic seizures, absence seizures, febrile seizures, complex partial seizures, and generalized tonic-clonic seizures.
    Note=Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 3 family.
  • Post-translational
    modifications
    N-glycosylated.
    Ubiquitinated by RNF19A; which induces proteasomal degradation.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab41761 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab41761.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up