Overview

  • Product nameRat LMAN1 peptide

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesRat
    • SequenceFDSFDNDGKKNNPAI
    • Amino acids159 to 173

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-LMAN1 antibody (ab32583)

    Neutralising

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Endoplasmic reticulum golgi intermediate compartment protein 53
    • ER-Golgi intermediate compartment 53 kDa protein
    • ERGIC-53
    • ERGIC53
    • ERGIC53 like protein
    • F5F8D
    • FMFD1
    • Gp58
    • Intracellular mannose specific lectin
    • Intracellular mannose-specific lectin MR60
    • Lectin mannose binding 1
    • Lectin mannose-binding 1
    • Lman1
    • LMAN1 like protein
    • LMAN1_HUMAN
    • MCFD1
    • MR60
    • Protein ERGIC-53
    see all
  • FunctionMannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
  • Tissue specificityUbiquitous.
  • Involvement in diseaseDefects in LMAN1 are THE cause of factor V and factor VIII combined deficiency type 1 (F5F8D1) [MIM:227300]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D1 is an autosomal recessive blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
  • Sequence similaritiesContains 1 L-type lectin-like domain.
  • Post-translational
    modifications
    The N-terminal may be partly blocked.
  • Cellular localizationEndoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.
  • Information by UniProt

References for Rat LMAN1 peptide (ab39824)

ab39824 has not yet been referenced specifically in any publications.

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