Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Rat
    • Sequence
      AISWLQGDDAAVRSH
    • Amino acids
      843 to 857

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SREBP2 antibody (ab28482)

    Neutralising

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • AI608257
    • bHLHd2
    • Class D basic helix-loop-helix protein 2
    • OTTHUMP00000028740
    • Processed sterol regulatory element-binding protein 2
    • SRBP2_HUMAN
    • SREBF 2
    • Srebf2
    • SREBF2 protein
    • SREBP 2
    • SREBP-2
    • SREBP2
    • SREBP2gc
    • sterol regulatory element binding factor 2
    • Sterol regulatory element binding protein 2
    • Sterol regulatory element binding transcription factor 2
    • Sterol regulatory element-binding transcription factor 2
    see all
  • Function
    Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
  • Tissue specificity
    Ubiquitously expressed in adult and fetal tissues.
  • Sequence similarities
    Belongs to the SREBP family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Post-translational
    modifications
    At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
  • Cellular localization
    Nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle > COPII-coated vesicle membrane. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
  • Information by UniProt

References

ab39821 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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