Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Rat
    • Sequence
      AISWLQGDDAAVRSH
    • Amino acids
      843 to 857

Associated products

Specifications

Our Abpromise guarantee covers the use of ab39821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-SREBP2 antibody (ab28482)

    Neutralising

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • AI608257
    • bHLHd2
    • Class D basic helix-loop-helix protein 2
    • OTTHUMP00000028740
    • Processed sterol regulatory element-binding protein 2
    • SRBP2_HUMAN
    • SREBF 2
    • Srebf2
    • SREBF2 protein
    • SREBP 2
    • SREBP-2
    • SREBP2
    • SREBP2gc
    • sterol regulatory element binding factor 2
    • Sterol regulatory element binding protein 2
    • Sterol regulatory element binding transcription factor 2
    • Sterol regulatory element-binding transcription factor 2
    see all
  • Function
    Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
  • Tissue specificity
    Ubiquitously expressed in adult and fetal tissues.
  • Sequence similarities
    Belongs to the SREBP family.
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Post-translational
    modifications
    At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7.
  • Cellular localization
    Nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle > COPII-coated vesicle membrane. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
  • Information by UniProt

References for Rat SREBP2 peptide (ab39821)

ab39821 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab39821.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up