Overview

  • Product name
    Rauwolscine hydrochloride
  • Description
    Potent α2 adrenergic antagonist
  • Alternative names
    • alpha-yohimbine
    • corynanthidine
    • isoyohimbine
  • Biological description
    Potent α2 adrenergic antagonist (Ki values are 3.5 (α2A), 0.37 (α2B), 0.13 (α2C) and 63.6 nM (α2D)). Partial 5-HT receptor antagonist (Ki = 14-40 nM). Centrally active following systemic administration.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Naselsky DP  et al. Rabbit alpha2-adrenoceptors: both platelets and adipocytes have alpha2A-pharmacology. J Pharmacol Exp Ther 298:219-25 (2001). Read more (PubMed: 11408545) »
  • Wainscott DB  et al. [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol 357:17-24 (1998). Read more (PubMed: 9459568) »
  • Bylund DB  et al. Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol Pharmacol 42:1-5 (1992). Read more (PubMed: 1353247) »
  • Weinshank RL  et al. Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A 89:3630-4 (1992). Read more (PubMed: 1565658) »
  • Timmermans PB  et al. A study of the selectivity and potency of rauwolscine, RX 781094 and RS 21361 as antagonists of alpha-1 and alpha-2 adrenoceptors. J Pharmacol Exp Ther 228:739-48 (1984). Read more (PubMed: 6142941) »
  • KOHLI JD & DE NN Pharmacological action of rauwolscine. Nature 177:1182 (1956). Read more (PubMed: 13334509) »

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