Overview

  • Product nameAnti-Rb2 p130 antibody
    See all Rb2 p130 primary antibodies
  • Description
    Rabbit polyclonal to Rb2 p130
  • Specificityab105741 reacts with the Spa3120 domain of pRb2 p130 from Human tissues.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Horse, Cow, Dog, Chimpanzee, Opossum, Orangutan
  • Immunogen

    Synthetic peptide with a Cysteine residue linker, corresponding to the Spa310 sequence of Rb2 p130.

  • Positive control
    • LNCaP whole cell extracts.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab105741 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/5000. Predicted molecular weight: 128 kDa.
ELISA 1/75000 - 1/100000.

Target

  • RelevanceTwo retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the "pocket domain." Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • 130 kDa retinoblastoma associated protein antibody
    • FLJ26459 antibody
    • p130 antibody
    • PRB 2 antibody
    • PRB2 antibody
    • Rb 2 antibody
    • Rb2 antibody
    • RBL 2 antibody
    • RBL2 antibody
    • RBR 2 antibody
    • RBR2 antibody
    • Retinoblastoma like 2 antibody
    • Retinoblastoma like protein 2 antibody
    • Retinoblastoma related gene antibody
    see all

Anti-Rb2 p130 antibody images

  • Anti-Rb2 p130 antibody (ab105741) at 1/500 dilution + LNCaP whole cell extracts
    Developed using the ECL technique

    Predicted band size : 128 kDa

References for Anti-Rb2 p130 antibody (ab105741)

ab105741 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"