Overview

  • Product name
    Anti-RbAp46 antibody (Biotin)
    See all RbAp46 primary antibodies
  • Description
    Rabbit polyclonal to RbAp46 (Biotin)
  • Conjugation
    Biotin
  • Specificity
    ab28500 recognises Retinoblastoma protein (Rb) associated protein 46 (RbAp46)
  • Tested applications
    Suitable for: WB, IHC, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Xenopus laevis, Cynomolgus monkey
  • Immunogen

    Synthetic peptide:

    MASKEMFEDTVEE

    , corresponding to N terminal amino acids 1 - 13 of Human RbAp46

  • Positive control
    • HeLa Cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab28500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 46 kDa (predicted molecular weight: 48 kDa).
IHC Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration.

Target

  • Function
    Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
  • Sequence similarities
    Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
    Contains 7 WD repeats.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • G1/S transition control protein binding protein RbAp46 antibody
    • Histone acetyltransferase type B subunit 2 antibody
    • Histone binding protein RBBP7 antibody
    • Histone-binding protein RBBP7 antibody
    • MGC138867 antibody
    • MGC138868 antibody
    • Nucleosome remodeling factor subunit RBAP46 antibody
    • Nucleosome-remodeling factor subunit RBAP46 antibody
    • RBAP46 antibody
    • RBBP 7 antibody
    • RBBP-7 antibody
    • RBBP7 antibody
    • RBBP7_HUMAN antibody
    • Retinoblastoma binding protein 7 antibody
    • Retinoblastoma binding protein p46 antibody
    • Retinoblastoma-binding protein 7 antibody
    • Retinoblastoma-binding protein p46 antibody
    • Retinoblastoma-binding protein RbAp46 antibody
    see all

References

ab28500 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab28500.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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