Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and endogenous RbAp 46, catalog ab3535. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • G1/S transition control protein binding protein RbAp46
    • Histone acetyltransferase type B subunit 2
    • Histone binding protein RBBP7
    • Histone-binding protein RBBP7
    • MGC138867
    • MGC138868
    • Nucleosome remodeling factor subunit RBAP46
    • Nucleosome-remodeling factor subunit RBAP46
    • RBAP46
    • RBBP 7
    • RBBP-7
    • RBBP7
    • RBBP7_HUMAN
    • Retinoblastoma binding protein 7
    • Retinoblastoma binding protein p46
    • Retinoblastoma-binding protein 7
    • Retinoblastoma-binding protein p46
    • Retinoblastoma-binding protein RbAp46
    see all
  • FunctionCore histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
  • Sequence similaritiesBelongs to the WD repeat RBAP46/RBAP48/MSI1 family.
    Contains 7 WD repeats.
  • Cellular localizationNucleus.
  • Information by UniProt

References for RbAp46 peptide (ab5013)

ab5013 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab5013.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"