The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and endogenous RbAp 46, catalog ab3535. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
G1/S transition control protein binding protein RbAp46
Histone acetyltransferase type B subunit 2
Histone binding protein RBBP7
Histone-binding protein RBBP7
Nucleosome remodeling factor subunit RBAP46
Nucleosome-remodeling factor subunit RBAP46
Retinoblastoma binding protein 7
Retinoblastoma binding protein p46
Retinoblastoma-binding protein 7
Retinoblastoma-binding protein p46
Retinoblastoma-binding protein RbAp46
FunctionCore histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Sequence similaritiesBelongs to the WD repeat RBAP46/RBAP48/MSI1 family. Contains 7 WD repeats.