Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab5013 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and endogenous RbAp 46, catalog ab3535. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

General Info

  • Alternative names
    • G1/S transition control protein binding protein RbAp46
    • Histone acetyltransferase type B subunit 2
    • Histone binding protein RBBP7
    • Histone-binding protein RBBP7
    • MGC138867
    • MGC138868
    • Nucleosome remodeling factor subunit RBAP46
    • Nucleosome-remodeling factor subunit RBAP46
    • RBAP46
    • RBBP 7
    • RBBP-7
    • RBBP7
    • RBBP7_HUMAN
    • Retinoblastoma binding protein 7
    • Retinoblastoma binding protein p46
    • Retinoblastoma-binding protein 7
    • Retinoblastoma-binding protein p46
    • Retinoblastoma-binding protein RbAp46
    see all
  • Function
    Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
  • Sequence similarities
    Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
    Contains 7 WD repeats.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab5013 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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