The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 59 kDa).
FunctionAs part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Tissue specificityUbiquitously expressed.
Sequence similaritiesContains 6 WD repeats.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.