Overview

  • Product name
  • Description
    Rabbit polyclonal to RbBP5
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Horse, Cow, Rhesus monkey, Gorilla, Orangutan, Bat, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region between residues 500 and the C-terminus (residue 538) of Human RbBP5 (NP_005048.2).

  • Positive control
    • Human colon adenocarcinoma and mouse teratoma tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab84511 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
    • Tissue specificity
      Ubiquitously expressed.
    • Sequence similarities
      Contains 6 WD repeats.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • RBBP 5 antibody
      • RBBP-5 antibody
      • RBBP5 antibody
      • RBBP5_HUMAN antibody
      • RBQ 3 antibody
      • RBQ3 antibody
      • Retinoblastoma binding protein 5 antibody
      • Retinoblastoma binding protein RBQ3 antibody
      • Retinoblastoma binding protein5 antibody
      • Retinoblastoma-binding protein 5 antibody
      • Retinoblastoma-binding protein RBQ-3 antibody
      • SWD1 antibody
      • SWD1, Set1c WD40 repeat protein, homolog antibody
      see all

    Images

    • ab84511, at 1/250 dilution, staining RbBP5 in formalin-fixed, paraffin-embedded human colon adenocarcinoma by Immunohistochemistry, using DAB staining.
    • ab84511, at 1/250 dilution, staining RbBP5 in formalin-fixed, paraffin-embedded mouse teratoma by Immunohistochemistry, using DAB staining.

    References

    This product has been referenced in:
    • Mather Q  et al. A novel protein expression signature differentiates benign lipomas from well-differentiated liposarcomas. Mol Clin Oncol 7:315-321 (2017). Read more (PubMed: 28781809) »
    • Yan L  et al. The B55a-containing PP2A holoenzyme dephosphorylates FOXO1 in islet ß-cells under oxidative stress. Biochem J 444:239-47 (2012). IHC-P ; Mouse . Read more (PubMed: 22417654) »

    See all 2 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab84511.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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