Overview

  • Product nameAnti-RBM10 antibody
    See all RBM10 primary antibodies
  • Description
    Rabbit polyclonal to RBM10
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    A region within synthetic peptide: PGSETQRRRR RRHRHSPTGP PGFPRDGDYR DQDYRTEQGE EEEEEEDEEE, corresponding to N terminal amino acids 74-123 of Human RBM10

  • Positive control
    • Daudi cell lysate. Human heart or lung sections.

Properties

Applications

Our Abpromise guarantee covers the use of ab26046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
WB Use a concentration of 1.4 µg/ml. Predicted molecular weight: 104 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionMay be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A).
  • Involvement in diseaseDefects in RBM10 are the cause of TARP syndrome (TARPS) [MIM:311900]. It is a disorder characterized by the Robin sequence (micrognathia, glossoptosis and cleft palate), talipes equinovarus and cardiac defects.
  • Sequence similaritiesContains 1 C2H2-type zinc finger.
    Contains 1 G-patch domain.
    Contains 1 RanBP2-type zinc finger.
    Contains 2 RRM (RNA recognition motif) domains.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationNucleus. In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs.
  • Information by UniProt
  • Database links
  • Alternative names
    • DXS8237E antibody
    • G patch domain containing protein 9 antibody
    • G patch domain-containing protein 9 antibody
    • GPATC9 antibody
    • GPATCH9 antibody
    • HGNC9896 antibody
    • KIAA0122 antibody
    • MGC1132 antibody
    • MGC997 antibody
    • Rbm10 antibody
    • RBM10_HUMAN antibody
    • RNA binding motif protein 10 antibody
    • RNA binding protein 10 antibody
    • RNA binding protein S1-1 antibody
    • RNA-binding motif protein 10 antibody
    • RNA-binding protein 10 antibody
    • RNA-binding protein S1-1 antibody
    • S1-1 antibody
    • TARPS antibody
    • ZRANB5 antibody
    see all

Anti-RBM10 antibody images

  • Anti-RBM10 antibody (ab26046) at 0.5 µg/ml + Daudi cell lysate

    Secondary
    HRP conjugated anti-Rabbit IgG diluted 1: 50,000 - 100,000

    Predicted band size : 104 kDa
  • Staining of human heart tissue with ab26046 at a 4.0-8.0ug/ml dilution. Positive labelled myocardial cells are indicated with arrows.
  • Staining of human lung tissue with ab26046 at a 4.0-8.0ug/ml dilution. Positive labelled epithelial cells of bronchiole are indicated with arrows.

References for Anti-RBM10 antibody (ab26046)

ab26046 has not yet been referenced specifically in any publications.

Product Wall

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