Overview

  • Product name
  • Description
    Rabbit polyclonal to RBM17
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Guinea pig, Cow, Dog, Pig, Xenopus laevis, Chimpanzee, Rhesus monkey, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 25-75 of Human RBM17 (NP_116294.1)

  • Positive control
    • Human Controls: Breast Carcinoma, Colon Carcinoma, Osteosarcoma, Ovarian Carcinoma, Prostate Carcinoma Mouse Controls: Hybridoma Tumor, Teratoma

Properties

Applications

Our Abpromise guarantee covers the use of ab124252 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.
  • Sequence similarities
    Contains 1 G-patch domain.
    Contains 1 RRM (RNA recognition motif) domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 45 kDa-splicing factor antibody
    • RBM 17 antibody
    • Rbm17 antibody
    • RNA binding motif protein 17 antibody
    • RNA-binding motif protein 17 antibody
    • SPF 45 antibody
    • SPF45 antibody
    • SPF45_HUMAN antibody
    • Splicing factor (45 kD) antibody
    • Splicing factor (45kD) antibody
    • Splicing factor 45 antibody
    • Splicing factor 45 kDa antibody
    • Splicing factor 45kDa antibody
    see all

Images

  • ab124252 at 1/250 dilution, staining Human RBM17 in Formalin-Fixed Paraffin-Embedded Human colon carcinoma tissue by immunohistochemistry.
  • ab124252 at 1/250 dilution staining Mouse RBM17 in Formalin-Fixed Paraffin-Embedded Mouse teratoma tissue by immunohistochemistry.

References

ab124252 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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