Overview

  • Product nameAnti-RBM25 antibody
    See all RBM25 primary antibodies
  • Description
    Rabbit polyclonal to RBM25
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Human, Saccharomyces cerevisiae, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 288-338 (

    DTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERERER

    ) of Mouse RBM25 Isoforms 1 and 2 (B2RY56; NM_027349).

  • Positive control
    • Mouse liver lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab125311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 99 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionRNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA.
  • Sequence similaritiesContains 1 PWI domain.
    Contains 1 RRM (RNA recognition motif) domain.
  • Post-translational
    modifications
    Sumoylated.
  • Cellular localizationNucleus speckle. Cytoplasm. Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint.
  • Information by UniProt
  • Database links
  • Alternative names
    • Arg/Glu/Asp rich protein, 120 kDa antibody
    • Arg/Glu/Asp-rich protein of 120 kDa antibody
    • fSAP94 antibody
    • functional spliceosome-associated protein 94 antibody
    • NET52 antibody
    • Protein S164 antibody
    • Rbm25 antibody
    • RBM25_HUMAN antibody
    • RED120 antibody
    • RNA binding motif protein 25 antibody
    • RNA binding region (RNP1, RRM) containing 7 antibody
    • RNA-binding motif protein 25 antibody
    • RNA-binding protein 25 antibody
    • RNA-binding region-containing protein 7 antibody
    • RNPC7 antibody
    • S164 antibody
    • Snu71 antibody
    • U1 small nuclear ribonucleoprotein 1SNRP homolog antibody
    see all

Anti-RBM25 antibody images

  • Anti-RBM25 antibody (ab125311) at 1 µg/ml + Mouse liver lysate at 10 µg

    Predicted band size : 99 kDa

References for Anti-RBM25 antibody (ab125311)

ab125311 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"