Overview

  • Product name
  • Description
    Mouse polyclonal to RBM38
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Recombinant full length protein corresponding to amino acids 1-239 of Human RBM38. (NP_05965.2).

  • Positive control
    • Transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab168445 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 26.29 kDa.

Target

  • Function
    RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Isoform 1, but not isoform 2, has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Plays a role in myogenic differentiation.
  • Sequence similarities
    Belongs to the RBM38 family.
    Contains 1 RRM (RNA recognition motif) domain.
  • Cellular localization
    Cytoplasm, cytosol. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • CLL associated antigen KW 5 antibody
    • CLL-associated antigen KW-5 antibody
    • HSRNASEB antibody
    • RBM38 antibody
    • RBM38_HUMAN antibody
    • RNA binding motif protein 38 antibody
    • RNA binding protein 38 antibody
    • RNA binding region (RNP1, RRM) containing 1 antibody
    • RNA binding region containing protein 1 antibody
    • RNA-binding motif protein 38 antibody
    • RNA-binding protein 38 antibody
    • RNA-binding region-containing protein 1 antibody
    • RNPC1 antibody
    • SEB4 antibody
    • SEB4B antibody
    • SEB4D antibody
    • ssDNA binding protein SEB4 antibody
    • ssDNA-binding protein SEB4 antibody
    see all

Images

  • All lanes : Anti-RBM38 antibody (ab168445) at 1 µg/ml

    Lane 1 : Transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 50 µg per lane.

    Secondary
    All lanes : Goat Anti-mouse HRP at 1/2500 dilution

References

ab168445 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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