Overview

  • Product name
  • Description
    Rabbit polyclonal to RC3H1
  • Host species
    Rabbit
  • Specificity
    At least three isoforms of RC3H1 are known to exist; ab156272 will detect all three isoforms.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide, corresponding to 18 amino acids near the C terminal of Human RC3H1 (NP_742068).

  • Positive control
    • HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab156272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 126 kDa.

Target

  • Function
    Represses ICOS function, an essential costimulatory receptor for follicular T-cells. May act as an ubiquitin ligase that regulates ubiquitin-dependent control of AU-rich mRNAs by AUF1/HNRPD and HUR/ELAVL1.
  • Tissue specificity
    Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver.
  • Sequence similarities
    Contains 1 C3H1-type zinc finger.
    Contains 1 RING-type zinc finger.
  • Cellular localization
    Cytoplasm. Localizes to cytosolic RNA granules, which are sites for regulating mRNA translation and decay, suggesting that it may bind RNA.
  • Information by UniProt
  • Database links
  • Alternative names
    • KIAA2025 antibody
    • Rc3h1 antibody
    • RC3H1_HUMAN antibody
    • RGD1563512 antibody
    • RING finger and C3H zinc finger protein 1 antibody
    • Ring Finger and CCCH type Zinc Finger Domain 1 antibody
    • RING finger protein 198 antibody
    • RNF198 antibody
    • Roquin antibody
    • RP5 1198E17.5 antibody
    • Sanroque protein antibody
    see all

Images

  • Anti-RC3H1 antibody (ab156272) at 1 µg/ml + HeLa cell lysate at 15 µg

    Predicted band size: 126 kDa

References

ab156272 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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