Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
Belongs to the prohibitin family.
Levels of expression in fibroblasts decrease heterogeneously during cellular aging.
Mitochondrion inner membrane. Cytoplasm. Nucleus. Also cytoplasmic and nuclear.