For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome
Investigate p21 and its effectors with highly cited tools.
We have put together the list of high impact products for your studies on the cyclin-dependent kinase (CDK) inhibitor p21 (also known as WAF1, CAP20, Cip1, and Sdi1). Browse the most-cited research targets and well-referenced products for better understanding p21 in cellular function.
The p21 toolkit
|Type: Rabbit monoclonal antibody|
Applications: ICC/IF, Flow Cyt, WB, IP, IHC-P
|Anti-p21 antibody||Biotin conjugated||ab79467|
|Goat Anti-Rabbit IgG H&L||Alexa Fluor® 488 conjugated||ab150077|
|IRDye® 800CW (preadsorbed)||ab216773|
p21 SimpleStep ELISA® kit
|Quantitatively measure p21 in human cell and tissue extracts. Get fast, reproducible results in 90 minutes.|
Range: 62.5 pg/ml - 4000 pg/ml
|Protein||Recombinant p21 protein||Human p21 protein for use in WB and as control1.||ab56278|
|Small molecule compound||Sorafenib (inhibitor)||p21 inhibitor in p53 mutant tumors2,3.||ab141966|
|Tenovin-1 (activator)||p21 activator and inducer of cell cycle arrest4.||ab120889|
Activation of p53-p21 pathway
DNA damaging agents activate the p53-p21 pathway causing cell cycle arrest and DNA repair5. This mechanism is exploited by chemotherapeutic agents that induce p21 as a means of inhibiting cancer progression. Investigating p21 regulation in a p53-dependent or -independent manner can form a key basis of tumor suppression6,7.
|Oxaliplatin||Inducer, inhibitor||Exhibits dual role in p53-dependent and -independent pathways. Causes G0-G1 arrest in p53 wild type cells and p21 degradation in p53 mutants8.||ab141054|
|Nocodazole||Inducer||p21 inducer that increases expression of p21 in a p53-dependent fashion in absence of DNA damage9,10.||ab120630|
|Cycloheximide (CHX)||Modulator||Induction of p21 during serum stimulation (indicating serum contains a p21 blocking element)7. CHX traditionally acts as a p21 inhibitor promoting apoptosis in serum-starved cells11.||ab120093|
|PMA||Inducer||p53-independent p21 induction via Sp1 binding sites within p21 promoter12.||ab120297|
Alexa Fluor is a registered trademark of Life Technologies. Alexa Fluordye conjugates contain(s) technology licensed to Abcam by Life Technologies.