Overview

  • Product name
    Anti-REBOV GP antibody
  • Description
    Rabbit polyclonal to REBOV GP
  • Host species
    Rabbit
  • Specificity
    ab190658 detects recombinant REBOV GP without the transmembrane region (REBOV rGPdTM). No cross reactivity to Sudan ebolavirus (SEBOV) GP, Zaire ebolavirus (ZEBOV) GP, Bundibugyo (BEBOV) GP or Marburg (MARV) GP, was observed in Western blot analysis.
  • Tested applications
    Suitable for: WBmore details
  • Immunogen

    Synthetic peptide corresponding to REBOV GP. (Reston Ebola virus glycoprotein).
    Database link: Q66800

Properties

Applications

Our Abpromise guarantee covers the use of ab190658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Predicted molecular weight: 42 kDa.

Target

  • Relevance
    REBOV GP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils. Delta-peptide does not seem to be involved in activation of primary macrophages B REBOV GP is a homodimer; disulfide-linked. The homodimers are linked by two disulfide bonds in a parallel orientation. Delta-peptide is a monome
  • Cellular localization
    Secreted
  • Alternative names
    • pre-sGP antibody
    • Pre-small/secreted glycoprotein antibody
    • small/secreted non-structural glycoprotein antibody
    • structural glycoprotein antibody

Images

  • All lanes : Anti-REBOV GP antibody (ab190658) at 0.05 µg/ml

    Lane 1 : REBOV rGPdTM supernatant at 15 µl
    Lane 2 : ZEBOV rGPdTM at 0.2 µg
    Lane 3 : SEBOV rGPdTM at 0.2 µg
    Lane 4 : MARV rGPdTM at 0.2 µg
    Lane 5 : BEBOV rGPdTM at 0.2 µg

    Predicted band size: 42 kDa



    REBOV GP is visualized as a broad band representing differing glycosylation patterns.

  • All lanes : Anti-REBOV GP antibody (ab190658) at 0.5 µg/ml

    Lane 1 : REBOV rGPdTM supernatant at 15 µl
    Lane 2 : ZEBOV rGPdTM at 0.2 µg
    Lane 3 : SEBOV rGPdTM at 0.2 µg
    Lane 4 : MARV rGPdTM at 0.2 µg
    Lane 5 : BEBOV rGPdTM at 0.2 µg

    Predicted band size: 42 kDa



    REBOV GP is visualized as a broad band representing differing glycosylation patterns.

References

ab190658 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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