Resistance to inhibitors of cholinesterase 4 homolog
Synaptosomal associated 25 kDa protein
Synaptosomal associated protein
Synaptosomal associated protein 25
Synaptosomal associated protein 25kDa
Synaptosomal-associated 25 kDa protein
Synaptosomal-associated protein 25
Synaptosomal-associated protein, 25-KD
Functiont-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
Tissue specificityNeurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.
Sequence similaritiesBelongs to the SNAP-25 family. Contains 2 t-SNARE coiled-coil homology domains.
Post-translational modificationsPalmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association.
Cellular localizationCytoplasm > perinuclear region. Cell membrane. Cell junction > synapse > synaptosome. Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region.