The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological activityab123769 is fully biologically active in homologous assays and in PDF-P1 3B9 cells stably transfected with rabbit GH receptors.
% SDS-PAGE. ab123769 is purified by proprietary chromatographic techniques. Purity is greater than 99% as determined by HPLC and SDS-PAGE.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
pH: 8.00 Constituent: 0.3% Sodium carbonate
This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionCentrifuge the vial prior to opening. Reconstitute in sterile H2O or 0.4 % NaHCO3 adjusted to pH 8-9 to a concentration = 100 µg/ml and sterile filtered. This solution can then be diluted into other aqueous buffers, preferably in the presence of carrier protein.
Growth hormone 1
Growth hormone, normal
Growth hormone, pituitary
Pituitary growth hormone
FunctionPlays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Involvement in diseaseDefects in GH1 are a cause of growth hormone deficiency isolated type 1A (IGHD1A) [MIM:262400]; also known as pituitary dwarfism I. IGHD1A is an autosomal recessive deficiency of GH which causes short stature. IGHD1A patients have an absence of GH with severe dwarfism and often develop anti-GH antibodies when given exogenous GH. Defects in GH1 are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Dwarfism is less severe than in IGHD1A and patients usually respond well to exogenous GH. Defects in GH1 are the cause of Kowarski syndrome (KWKS) [MIM:262650]; also known as pituitary dwarfism VI. Defects in GH1 are a cause of growth hormone deficiency isolated type 2 (IGHD2) [MIM:173100]. IGHD2 is an autosomal dominant deficiency of GH which causes short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
Sequence similaritiesBelongs to the somatotropin/prolactin family.