ReconstitutionReconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
C C motif chemokine ligand 20
C-C motif chemokine 20
CC chemokine LARC
Chemokine (C C motif) ligand 20
Chemokine CC motif ligand 20
Liver and activation-regulated chemokine
Macrophage inflammatory protein 3 alpha
MIP 3 alpha
Small inducible cytokine A20
Small inducible cytokine subfamily A (Cys Cys) member 20
Small-inducible cytokine A20
FunctionChemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213.
Tissue specificityExpressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Sequence similaritiesBelongs to the intercrine beta (chemokine CC) family.
Post-translational modificationsC-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.