Overview

Description

  • Nature
    Recombinant
  • Source
    Yeast
  • Amino Acid Sequence
    • Accession
    • Species
      Cow
    • Sequence
      ATTDLNSSTD SSGSASVTSD VSIESAEATV CTVTLEKTSA GLGFSLEGGK GSLHGDKPLT VNRIFKGLAS EQSDTVQPGD EIVHLAGTAM QGLTRFEAWN IIKALPDGPV TIVLRRKSLQ SKGTPAAGDP
    • Molecular weight
      13 kDa
    • Amino acids
      498 to 627

Specifications

Our Abpromise guarantee covers the use of ab117220 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Form
    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Constituents: 90% PBS, 10% Trehalose

  • Reconstitution
    Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.

General Info

  • Alternative names
    • HGNC:5980
    • HsT19289
    • IL-16
    • IL16
    • IL16_HUMAN
    • Interleukin 16 precursor
    • Interleukin-16
    • LCF
    • Lymphocyte chemoattractant factor
    • Neuronal interleukin 16
    • NIL16
    • prIL 16
    • PrIL16
    • Prointerleukin 16
    see all
  • Function
    Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
    Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
    Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
  • Tissue specificity
    Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T cell proliferation.
  • Sequence similarities
    Contains 4 PDZ (DHR) domains.
  • Post-translational
    modifications
    Isoform 3 is synthesized as a chemo-attractant inactive precursor in hemopoietic tissues and is proteolytically cleaved by caspase-3 to yield IL-16.
  • Cellular localization
    Cytoplasm; Cytoplasm. Nucleus and Secreted.
  • Information by UniProt

References

ab117220 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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