Overview

Description

  • NatureRecombinant
  • SourceYeast
  • Amino Acid Sequence
    • SpeciesCow
    • SequenceMVLSGALCFR MKDAALKVLY LHDNQLLAGG LQAGKVIKGE EISVVPNRSL DAKLSPVILG VHGGSQCLSC GTGQEPTLKL EPVNIMELYH SAEKSKKFTF YRRDTGLTSS FESAAYPGWF LCTVPEADQP LQITQLPKDT SWDNPIIDFY FQQCD

Specifications

Our Abpromise guarantee covers the use of ab87465 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab87465 is purified by Ion-exchange chromatography.
  • FormLyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    Preservative: None
    Constituents: 10% Trehalose, 1.0X PBS

  • ReconstitutionReconstitute with sterile Phosphate-buffered saline containing at least 0.1% carrier protein. Reconstituted protein is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

General Info

  • Alternative names
    • AI413231
    • Family of interleukin 1 delta
    • FIL1
    • FIL1 delta
    • FIL1(DELTA)
    • FIL1D
    • Fil1delta
    • I36RA_HUMAN
    • IL 1 delta
    • IL 1 related protein 3
    • IL 1F5 (IL 1HY1, FIL1 delta, IL 1RP3, IL 1L1, IL 1 delta)
    • Il 1h3
    • IL 1HY1
    • IL 1L1
    • IL 1ra homolog
    • IL 1ra homolog; IL1F5 (Canonical product IL 1F5a)
    • IL 1RP3
    • IL-1 delta
    • IL-1-related protein 3
    • IL-1F5
    • IL-1HY1
    • IL-1L1
    • IL-1ra homolog 1
    • IL-1RP3
    • IL1F5
    • IL1HY1
    • IL1L1
    • IL1RP3
    • IL36RA
    • IL36RN
    • Interleukin 1 delta
    • Interleukin 1 family member 5
    • Interleukin 1 family member 5 (delta)
    • Interleukin 1 HY1
    • Interleukin 1 like protein 1
    • Interleukin 1 receptor antagonist homolog 1
    • Interleukin 36 receptor antagonist
    • Interleukin-1 delta
    • Interleukin-1 family member 5
    • Interleukin-1 HY1
    • Interleukin-1 receptor antagonist homolog 1
    • Interleukin-1-like protein 1
    • Interleukin-36 receptor antagonist protein
    • MGC29840
    • PSORP
    • RP23-176J12.6
    see all
  • FunctionIs a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
  • Tissue specificityPredominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
  • Involvement in diseaseDefects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.
  • Sequence similaritiesBelongs to the IL-1 family.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant Cow IL36RN protein (ab87465)

ab87465 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"