Recombinant Cow PI 3 Kinase p85 beta protein (ab91399)



  • NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • SpeciesCow

Associated products


Our Abpromise guarantee covers the use of ab91399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications


  • Purity> 90 % SDS-PAGE.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, pH 7.5

General Info

  • Alternative names
    • p85
    • p85 beta
    • P85B
    • P85B_HUMAN
    • Phosphatidylinositol 3 kinase
    • Phosphatidylinositol 3 kinase regulatory beta subunit
    • Phosphatidylinositol 3 kinase regulatory subunit beta
    • Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2
    • Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta)
    • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
    • Phosphatidylinositol 3-kinase regulatory subunit beta
    • Phosphoinositide 3 kinase regulatory subunit 2
    • Phosphoinositide 3 kinase regulatory subunit 2 (beta)
    • Phosphoinositide 3 kinase regulatory subunit polypeptide 2
    • Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta)
    • Phosphoinositide 3 kinase, regulatory subunit 2 (beta)
    • Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta)
    • PI3 kinase p85 beta subunit
    • PI3 kinase p85 subunit beta
    • PI3-kinase regulatory subunit beta
    • PI3-kinase subunit p85-beta
    • PI3K
    • PI3K regulatory subunit beta
    • PIK3R 2
    • PIK3R2
    • PtdIns 3 kinase p85 beta
    • PtdIns-3-kinase regulatory subunit beta
    • PtdIns-3-kinase regulatory subunit p85-beta
    see all
  • FunctionRegulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.
  • Involvement in diseaseMegalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1
  • Sequence similaritiesBelongs to the PI3K p85 subunit family.
    Contains 1 Rho-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • DomainThe SH2 2 domain is required for interaction with FBXL2 and PTPN13.
  • Post-translational
    Phosphorylated in response to signaling from activated receptor-type protein kinases (PubMed:19690332, PubMed:20068231). Dephosphorylated by PTPRJ (PubMed:18348712). Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination (PubMed:23604317).
    Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2.
  • Information by UniProt

Recombinant Cow PI 3 Kinase p85 beta protein images

  • SDS-PAGE showing ab91399 at approximately 83.5kDa.

References for Recombinant Cow PI 3 Kinase p85 beta protein (ab91399)

ab91399 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab91399.
Please use the links above to contact us or submit feedback about this product.