This product is an active protein and may elicit a biological response in vivo, handle with caution.
Cyclophilin like protein
peptidyl prolyl cis trans isomerase B
Peptidyl prolyl cis trans isomerase B precursor
Peptidyl-prolyl cis-trans isomerase B
Peptidylprolyl isomerase B
peptidylprolyl isomerase B (cyclophilin B)
FunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Involvement in diseaseDefects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9) [MIM:259440]. OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients.
Sequence similaritiesBelongs to the cyclophilin-type PPIase family. PPIase B subfamily. Contains 1 PPIase cyclophilin-type domain.
Cellular localizationEndoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.