Recombinant E. coli Mannose Phosphate Isomerase protein (ab56727)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesEscherichia coli

Specifications

Our Abpromise guarantee covers the use of ab56727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Functional Studies

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C.

    Constituent: 42.3% Ammonium sulphate

General Info

  • Alternative names
    • PMI1
    • CDG1B
    • FLJ39201
    • Mannose 6 phosphate isomerase
    • Mannose-6-phosphate isomerase
    • MANNOSEPHOSPHATE ISOMERASE
    • MGC94106
    • MPI
    • MPI_HUMAN
    • Phosphohexomutase
    • Phosphomannose isomerase
    • phosphomannose isomerase 1
    • PMI
    see all
  • FunctionInvolved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
  • Tissue specificityExpressed in all tissues, but more abundant in heart, brain and skeletal muscle.
  • PathwayNucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.
  • Involvement in diseaseDefects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B) [MIM:602579]; also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy.
  • Sequence similaritiesBelongs to the mannose-6-phosphate isomerase type 1 family.
  • Cellular localizationCytoplasm.
  • Information by UniProt

References for Recombinant E. coli Mannose Phosphate Isomerase protein (ab56727)

ab56727 has not yet been referenced specifically in any publications.

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