RelevanceNitroreductase shows the ability to reduce quinines. It is an enzyme for activating prodrugs in antibody directed enzyme prodrug therapy.
It is also capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species.
Recombinant E. coli Nitroreductase protein images
SDS-PAGE - Nitroreductase protein (ab97948)
15% SDS-PAGE showing ab97948 at approximately 26kDa (3µg).
References for Recombinant E. coli Nitroreductase protein (ab97948)
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